The GLBA Safeguards Rule mandates financial institutions to protect the confidentiality and integrity of consumer financial information. It requires these institutions to conduct thorough information security risk self-assessments, implement specified safeguards to address identified risks, and ensure the security of consumer information when dealing with third-party vendors. The rule emphasizes developing, implementing, and maintaining a comprehensive information security program, tailored to the size and complexity of the institution, to manage risks effectively and safeguard sensitive consumer information against unauthorized access or threats.